OUR SCIENCE:Validated human biology unambiguously links thyroid hormone to the production of myelin, the protective covering on neurons. Our lead program, ABX-002, engages thyroid hormone receptors selectively in the brain to restore myelin to demyelinated axons to halt and potentially reverse the progressive course of multiple sclerosis and other demyelinating diseases.
The ABX-002 program leverages our brain-targeting chemistry platform to maximize on-target exposure in the CNS and minimize peripheral exposure and the potential for unwanted side effects. We are actively pursuing a similar chemical strategy with other target classes where a dramatic shift in relative brain exposure can deliver future regenerative medicines for CNS disorders.
